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Signaling is at the core of coordination between cells in multicellular organisms. Many experimental and computational studies are dedicated to deciphering the mechanisms underlying the specificity, efficiency and biological outputs of cell signaling networks. The primary role of the dynamical information conveyed by these networks is becoming increasingly evident, as revealed by the observation of delays, oscillations, or differential control of transient versus sustained responses.
In this one-day symposium, we aim at presenting a state-of-the-art view of how cells encode and decode spatio-temporal signals. The question is addressed through a combined experimental and modelling approach. Presentations will focus on interdisciplinary works at the interface between biology, physics and mathematics and investigating different signaling pathways (calcium, G-protein-coupled receptors and tyrosine-kinase receptors) involved in various biological contexts such as cellular adhesion, morphogenesis, endocrinology, neuroscience or cancer. The interdisciplinary approach is expected to lead to a unique cross-fertilization of ideas between scientists focusing on widely different time-regulated biological systems.
The symposium will take place on March 20th, 2020 at the BioPark auditorium, 11 rue Watt, Paris 75013.
Due to the COVID-19 outbreak, this symposium is cancelled and will be rescheduled at a later date.
Scientific organization committee: Frédérique Clément, Geneviève Dupont, Laurent Combettes
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PROGRAM
All talks are 30 min + 10 min discussion
9:00 - 10:00 am. Registration, welcome
9:45 am. Introduction
Session 1: Calcium signaling
10:00- 10:40. Hugues Berry
INRIA Inria Grenoble Rhône-Alpes, équipe-projet Beagle
Spatio-temporal dynamics of calcium signalling in tiny subcellular domains : the case of astrocyte processes
10:40 - 11:20. Ursula Kummer
COS Heidelberg, Germany. Modelling of Biological Processes
Amplitude versus frequency coding in calcium oscillations
Session 2: GPCR signaling
11:20 - 12:00. Eric Reiter
UMR Physiologie de la Reproduction et des Comportements, Tours, France. Equipe BIOS (Biologie et bioinformatique des systèmes de signalisation)
Role of kinetics and trafficking in GPCR-mediated signaling
12:00 - 12:40. Margaritis Voliotis
University of Exeter, UK. Centre for Predictive Modeling in Healthcare
Information transfer in gonadotropin-releasing hormone (GnRH) signaling
12:40 - 2:00 pm. Lunch, networking
Session 3: Signaling and decision making
2:00 - 2:40. Olivier Pertz
University of Bern, Switzerland. Institute of Cell Biology
Decoding and Re-encoding MAPK Fate Decision Signaling
2:40 - 3:20. Madalena Chaves
INRIA Sophia Antipolis - Méditerranée, équipe-projet Biocore
A positive feedback loop in apoptosis to explain heterogeneity in cell response to cancer drugs
Session 4: Onset and propagation of oscillations in signaling
3:20 - 4:00. Jacques-Alexandre Sepulchre
Institut de Physique de Nice
Modeling the onset of periodic and excitable dynamics in signaling motifs
4:00 - 4:40. Joseph d’Alessandro
Institut Jacques Monod, Paris. Equipe Adhésion cellulaire et mécanique
Autonomous oscillations of confined epithelia : a dance-based rangefinder
