Signaling is at the core of coordination between cells in multicellular organisms. Many experimental and computational studies are dedicated to deciphering the mechanisms underlying the specificity, efficiency and biological outputs of cell signaling networks. The primary role of the dynamical information conveyed by these networks is becoming increasingly evident, as revealed by the observation of delays, oscillations, or differential control of transient versus sustained responses.
In this one-day symposium, we aim at presenting a state-of-the-art view of how cells encode and decode spatio-temporal signals. The question is addressed through a combined experimental and modelling approach. Presentations will focus on interdisciplinary works at the interface between biology, physics and mathematics and investigating different signaling pathways (calcium, G-protein-coupled receptors and tyrosine-kinase receptors) involved in various biological contexts such as cellular adhesion, morphogenesis, endocrinology, neuroscience or cancer. The interdisciplinary approach is expected to lead to a unique cross-fertilization of ideas between scientists focusing on widely different time-regulated biological systems.
This symposium, initially scheduled to take place in Paris in March 2020, will be organized online on March 18, 2021.
Several short communications will be selected from submitted abstracts, upload your abstract upon registration. Note that abstracts dealing with inter-disciplinary approaches will be favored. Deadline for abstract submission: February 12th, 2021.
Scientific organization committee: Frédérique Clément, Geneviève Dupont, Laurent Combettes
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Session 1: Calcium signaling
INRIA Inria Grenoble Rhône-Alpes, Beagle team
Spatio-temporal dynamics of calcium signalling in tiny subcellular domains : the case of astrocyte processes
COS Heidelberg, Germany. Modelling of Biological Processes
Amplitude versus frequency coding in calcium oscillations
Session 2: GPCR signaling
"Physiology of Reproduction and Behaviors" lab, Tours, France. BIOS Team (Biology and bioinformatics of signaling systems)
Role of kinetics and trafficking in GPCR-mediated signaling
University of Exeter, UK. Centre for Predictive Modeling in Healthcare
Information transfer in gonadotropin-releasing hormone (GnRH) signaling
Session 3: Signaling and decision making
University of Bern, Switzerland. Institute of Cell Biology
Decoding and Re-encoding MAPK Fate Decision Signaling
INRIA Sophia Antipolis - Méditerranée, Biocore team
A positive feedback loop in apoptosis to explain heterogeneity in cell response to cancer drugs
Session 4: Onset and propagation of oscillations in signaling
Nice Physics Institute
Modeling the onset of periodic and excitable dynamics in signaling motifs
Institut Jacques Monod, Paris. Cell Adhesion and Mechanics team
Autonomous oscillations of confined epithelia : a dance-based rangefinder