République Française Inserm
Institut thématique Biologie cellulaire, développement et évolution

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Program

OCTOBER 4, 2023

2:00 p.m.-2:10 p.m. Welcome by the organizers

Session 1: ER stress-1

Chairperson: Eric Chevet, Rennes, France

  1. 2:10-2:40 p.m.: “Lipid bilayer stress in the endoplasmic reticulum of kidney cells”, Matias SIMONS, Universität Klinikum Heidelberg, Germany.

 

  1. Selected short talks
  1. 2:40-2:55 p.m.: “Unravelling ER stress sensor cross talk”. Susan Logue, University of Manitoba, Winnipeg, Canada
  1. 2:55-3:10 p.m.: “UNC93B1 controls the activation of STING “. Bénédicte Manoury, INEM U1151, Paris, France
  1. 3:10-3:25 p.m.: “PERK-dependent reciprocal crosstalk between ER and non-centrosomal microtubules coordinates ER architecture and cell shape”. Miguel Sanchez-Alvarez, IIBm-CSIC, Madrid, Spain
  2. 3:25-3:40 p.m.: “The ATF6 branch of the unfolded protein response is implicated in the establishment of the senescent phenotype in fibroblasts”. Joëlle Giroud, University of Lille - Oncolille; University of Namur – URBC, France/Belgium

 

3:40-4:20 p.m Coffee break

 

Session 2: ER dynamics-1

Chairperson: Thierry Galli, Paris, France

  1. 4:20-4:50 p.m.: “Wolfram syndrome, a prototypic MAMopathy: from physiopathology to therapy. Benjamin DELPRAT, Molecular Mechanisms in Dementia, Montpellier, France.
  2. 4:50-5:20 p.m.: “Structural and functional characterization of the OSBP/VAP-A complex”.  Bruno MESMIN, Dynamics of lipid membranes and protein coats, IPMC, Nice, France.

 

Selected short talks

  1. 5:20-5:35 p.m.: “A critical role for the ER Membrane Complex (EMC) in lipid droplet homeostasis”. Colin Adrain, Queen's University, Belfast, Northern Ireland
  2. 5:35-5:50 p.m.: “A pathological perinuclear contact site that shuts down sterol biosynthesis”. Maria Moriel-Carretero, Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), Montpellier, France

5:50-6:35 p.m. Keynote

“Modulating the UPR: from therapies to safe havens”. Giovanna MALLUCCI, Altos Labs Cambridge Institute of Science, UK

 

OCTOBER 5, 2023

Session 3: ER stress-2

Chairperson: Emilie Boncoeur, Grenoble, France

Invited talks

  1. 9:00-9:30 a.m.: “Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism”. Sivan HENIS-KORENBLIT, Bar-Ilan University, Ramat-Gan, Israel.
  2. 9:30-10:00 a.m.: “Endoplasmic Reticulum stress signaling upon moderate calcium changes: experiments and modeling”. Geneviève DUPONT, Unit of Theoretical Chronobiology, Brussels, Belgium.

Selected short talks

  1. 10:00-10:15 a.m.: “RNA metabolism instructs the duration of UPR signaling”. Anna Babour, Inserm, Paris, France

 

10:15-10:45 a.m. Coffee break 

 

  1. 10:45-11:00 a.m.: “Unfolded Protein Response triggers an Alternative Splicing program in eukaryotic cells“. Kevin Rouault-Pierre, Barts Cancer Institute, Queen Mary University of London, London, UK

 

  1. 11:00-11:15 a.m.: “ER stress disrupts actin and organelle dynamics during cell migration”. Pablo Saez, Cell Communication and Migration Laboratory, Department of Biochemistry and Molecular Cell Biology (IBMZ), Center for Experimental Medicine, Hamburg, Germany

 

11:15 a.m.-12:00 p.m. Keynote

“GETting to the Endoplasmic Reticulum – Hairpin proteins as non-canonical targeting clients of the “Guided Entry for Tail-anchored proteins” pathway”. Blanche SCHWAPPACH-PIGNATARO, Universitätsklinikum Hamburg-Eppendorf & Center for Biochemistry and Molecular Cell Biology”, Universitätsmedizin Göttingen, Germany.

12:00-2:00 p.m. Lunch

Session 4: ER dynamics-2

Chairperson: Laurent Combettes, Gif-sur-Yvette, France

Selected short talks

  1. 2:00-2:15 p.m.: “Single molecule protein dynamics at ER-organelle contact sites”. Jonathon Nixon-Abell, University of Cambridge, Cambridge, UK
  2. 2:15-2:30 p.m.: “Luminal transport rates through intact endoplasmic reticulum limit the magnitude of localised calcium signals”. Cécile Crapart, University of Cambridge, Cambridge, UK
  3. 2:30-2:45 p.m.: “Late endosomal autophagic secretion regulates cell fitness and communication “. Somya Vats, IPNP Inserm U1266, Paris, France
  4. 2:45-3 :00: “Relating structure and function of the axonal tubular ER network in Drosophila”. Cahir O’Kane, University of Cambridge, Cambridge, UK

Invited talks

  1. 3 :00-3:30 p.m.: "Single particle trajectories vs photoactivation to probe trafficking in the ER”. David HOLCMAN, Group of Data Modeling, Computational NeuroBiology and Predictive Medicine, IBENS, Paris, France.
  2. 3:30-4:00 p.m.: “ER protein acetylation in Apicomplexa parasites”. Carmela GIGLIONE, Protein Maturation, Cell Fate and Therapeutics, I2BC, Paris, France.

 

4:00-4:30 p.m. Coffee break

Session 5: Folding & quality control

Chairperson: Susan Logue, Winnipeg, Canada

Selected short talks

  1. 4:30-4:45 p.m.: “Xport-A functions as a chaperone by stabilizing the first five transmembrane domains of Rhodopsin-1 “. Pedro Domingos, ITQB-UNL, Oeiras, Portugal
  2. 4:45-5:00 p.m.: “Mechanism of signal-anchor triage during early steps of membrane protein insertion”. Haoxi Wu, MRC-LMB, Cambridge, UK
  3. 5:00-5:15 p.m.: “The UPR-induced chaperone AGR2 is a discriminative indicator for the microsatellite instability (MSI) phenotype”. Frédéric Delom, Université de Bordeaux/Inserm, Bordeaux, France

 

5:15-6:30 p.m. Poster Session

Cocktail

October 6, 2023

Chairperson: Sivan Henis-Korenblit, Ramat-Gan, Israel

Session 6: Organelle & protein dynamics

Invited talk

  1. 9:00-9:30 a.m.: “Targeted inhibition of TANGO1 ameliorates fibrosis”. Ishier RAOTE, Secreting the Extracellular Matrix, Institut Jacques Monod, Paris, France.

Selected short talks

  1. 9:30-9:45 a.m.: “A fluorogenic chemically induced dimerization technology for controlling, imaging and sensing protein proximity”. Franck Perez, CNRS UMR144 - Institut Curie, Paris, France
  1. 9:45-10:00 a.m.: “Stimulation of endosomal secretion by optogenetic induction of membrane contact sites”. Marine Bretou, IPNP Inserm U1266, Paris, France
  2. 10:00-10:15 a.m.: “How do peripheral proteins get to the endoplasmic reticulum surface in yeast?”. Sivan Arad, Weizmann Institute of Science, Rehovot, Israel

10:15-10:45 a.m.: Coffee break

  1. 10:45-11:00 a.m.: “IRE1 RNASE controls CD95-mediated cell death”. Elodie Lafont, Inserm U1242, Rennes, France
  2. 11:00-11:15 a.m.: “Translocation into the endoplasmic reticulum: when better is worst”.  Magda Cannata-Serio, CNRS UMR144 - Institut Curie, Paris, France
  3. 11:15 -11:30 a.m.: “Using the Endoplasmic Reticulum to regulate Amyloid Precursor Protein’s proteolytic cleavage”. Pierre Parutto, University of Cambridge, Cambridge, UK.

Invited talk

  1. 11:30-12:00 p.m.: “The role of the phagophore-endoplasmic reticulum membrane contact sites in autophagy”. Fulvio REGGIORI, Department of Biomedicine, Aarhus University & Aarhus Institute of Advanced Studies, Denmark.

 

  1. 12:00 p.m: Meeting end

 

 

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