FROM GAMETES TO EMBRYO: basic research and clinical applications

Paris November 24, 2022

Maud Borensztein

Institut de Génétique Moléculaire de Montpellier, France

Our group investigates X-chromosome reactivation during the specification of the germline. This female-specific reprogramming pathway is a paradigm of epigenetic resetting and fine gene-regulation control. A better understanding of the mechanisms involved in gene expression regulation and epigenetic memory is crucial, especially in the very unique context of the germ line formation.



Deborah Bourc'his

Epigenetics, RNA and genome dynamics, Institut Curie, Paris, France

The interest of our team is focused on understanding the nature and the role of the epigenetic information within the peri-conception window, which encompasses gametogenesis, fertilization and early embryonic development.


Patricia Fauque

Laboratoire de Biologie de la Reproduction-CECOS, CHU Dijon Bourgogne, and Université Bourgogne Franche-Comté - Equipe Génétique des Anomalies du Développement (GAD) INSERM UMR1231, Dijon, France

Recent publications



Thomas Fréour

Service de médecine et biologie de la reproduction, gynécologie médicale, CHU de Nantes; INSERM UMR1064, CR2TI, Nantes; University of Nantes

Our research team works in the field of stem cell fate, developmental biology and fertility. More specifically, we explore cell fate during human preimplantation development. We also conduct several clinical studies in the field of human fertility.

Recent publications


Takashi Hiiragi

Hubrecht Institute, Utrecht, The Netherlands

Self-organization is a defining feature of living systems and entails complex interplay between molecular, cellular and mechanical signals across various spatio-temporal scales. Using early mammalian embryos as a model, the Hiiragi group adopts a variety of methods including genetics, microscopy, biophysics, engineering and modelling, to investigate how self-organised forms and patterns emerge from a spherical mass of cells.


Kikuë Tachibana

Max Planck Institute of Biochemistry, Martinsried, Germany

The department of Kikuë Tachibana is investigating the mechanisms of totipotency reprogramming, spatial chromatin reorganization and zygotic genome activation (ZGA) in mouse embryos. The group uses an interdisciplinary approach combining mechanistic cell biology with genetics, genomics, bioinformatics and biochemistry.



Magdalena Zernicka-Goetz

Mammalian Embryo and Stem Cell Groups. Cambridge, UK and Caltech, USA

In our group we investigate molecular and cellular mechanisms underlying the specification of cell lineages and patterning. The mouse embryo is our major model system because this allows us to combine cell biological and molecular genetic approaches with live embryo imaging to study development in a system that is close to our own, human development.



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